----- Original Message -----
From : Contraception and Reproductive Medicine <do-not-reply@springernature.com>
To : <kuslee@pusan.ac.kr>
Cc :
Sent : 2024-07-08 22:12:57
Subject : Contraception and Reproductive Medicine: Decision on "Comparison of ultra-long gonadotropin releasing hormone agonist versus standard 

downregulation in women with adenomyosis undergoing frozen thawed embryo transfer: A randomized clinical trial"


Dear Dr Lee,

Thank you for your help with the manuscript, "Comparison of ultra-long gonadotropin releasing hormone agonist versus standard downregulation in women with adenomyosis 

undergoing frozen thawed embryo transfer: A randomized clinical trial", which you recently reviewed for Contraception and Reproductive Medicine.

For your records, the decision on this manuscript, based partly on your input, was: Revise. Any comments to authors have been appended below.

We greatly appreciate your assistance and participation in the review process for Contraception and Reproductive Medicine and hope that we can continue to benefit from your 

expertise on future submissions.

You can keep track of your reviewer work on the new Reviewer dashboard associated with your Springer Nature account.
https://reviewer.springernature.com/dashboard/reviews?filter=completed

Kind regards,
Editorial Assistant
Contraception and Reproductive Medicine

Reviewer 1


Attachments:
• https://reviewer-feedback.springernature.com/download/attachment/ebd903f5-de97-4191-acdb-44910811c6f5

Reviewer 2
This conclusions of the article would be strengthened if cleavage stage and blastocyst transfers would be analyzed separately.

Reviewer 3
Authors examined whether standard downregulation in women with adenomyosis undergoing frozen thawed ET could be superior to ultralong GnRH agonist in women with 

adenomyosis undergoing frozen thawed ET. Their results shows that downregulation of standard GnRH agonists before FET may be the preferred embryo transfer protocol in 

women with adenomyosis. This RCT is very interesting considering the efficacy of standard downregulation in women with adenomyosis undergoing frozen thawed ET.
However, this study has a critical concern in concluding this result.

1. The number of embryos transferred were not similar in both groups.
Therefore, the pregnancy rate was higher in standard downregulation than ultralong GnRH agonist group. Another concern is that chemical pregnancy rate was slight higher in 

ultralong GnRH agonist than GnRH agonist group. A rationale for this issue is required.
2. A larger number of samples will be required to ensure the efficacy of standard downregulation in women with adenomyosis undergoing frozen thawed ET. Samples collected 

from a cohort of 72 women seem insufficient to conclude this result.